Probe to unlock cell secrets

Sept. 14, 2006
Scientists are trying to create drugs capable of targeting some of the most devastating human diseases.

To do so they must first decode exactly how cells or cell groups communicate with each other and react to surrounding biomolecules. But it is difficult to observe complex cellular interactions, as they would take place in the human body, without disturbing the process or missing a lot of what goes on.

To get around the problem, Georgia Tech researchers have built a nanoscale Scanning Mass Spectrometry (SMS) probe. It captures both the biochemical makeup and topography of complex biological objects, in situ. The SMS probe gently pulls biomolecules at a specific point on the cell-tissue surface. Ions produced by the action go to a mass spectrometer for analysis.

The probe dynamically images the cellular surface and maps cellular activity and communication, potentially in real time. In scanning mode, it could create movies of cell biochemical activity with high spatial and temporal resolution. The SMS probe readily integrates with atomic force microscopes and other scanning probes, letting it image biochemical activity as well as changes in cell-tissue topology.

How the SMS probe works.


Sponsored Recommendations

NEW Low Profile, Ultra Compact Power Supplies

March 13, 2024
Learn more HERE about Altech's Power supplies!

Altech's Liquid Tight Strain Relifs Catalog

March 13, 2024
With experienced Product Engineers and Customer Service personnel, Altech provides solutions to your most pressing application challenges. All with one thought in mind - to ensure...

Industrial Straight-Through Cable Gland

March 13, 2024
Learn more about Altech's cable glands and all they have to offer for your needs!

All-In-One DC-UPS Power Solutions

March 13, 2024
Introducing the All-In-One DC-UPS, a versatile solution combining multiple functionalities in a single device. Serving as a power supply, battery charger, battery care module,...

Voice your opinion!

To join the conversation, and become an exclusive member of Machine Design, create an account today!